Svitlana V. Prylutska

Date and place of birth: 20.02.1977, Vinnytsa region, Ukraine             

Nationality: Ukraine

Scientific interests: biochemical mechanisms of action and application of nanomaterials in biomedicine and agricultural technologies.

Scopus (2023): number of publications: 91; h-index =26 (Prylutska S.V. author identifier 6507378333).

Scientific degree: Doctor of Sciences (Biol.), specialty 03.00.20 – biotechnology, Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv (2020).

Academic status: professor (2022).

Position: head of Plant Physiology, Biochemistry and Bioenergetics Department, National University of Life and Environmental Sciences of Ukraine (NULES).

Affiliation and official address:

National University of Life and Environmental Science of Ukraine (NULES), Department of Plants Physyology, Biochemistry and Bionergetics, Heroyiv Oborony Str., 15, 03041 Kyiv, Ukraine

E-mail: [email protected]

Education:

• 1997-2001 Bachelor (First Class Diploma, Biological Faculty, Dept. of Biochemistry, Taras Shevchenko National University of Kyiv (KNU))
• 2001-2002 Specialist (First Class Diploma, Biological Faculty, Dept. of Biochemistry, KNU)
• 2002-2004 Post-graduate student (Biological Faculty, Dept. of Biochemistry, KNU)
• 2008 Candidate of Sciences (Biochemistry, PhD), KNU
• 2020 Doctor of Sciences (Biotechnology, Dr. Sci), O.V. Palladin Institute of Biochemistry, NAS of Ukraine       

Сareer/Employment:

• 2004 - 2008 Leading Engineer (Research Department, KNU)
• 2008 - 2009 Junior Research Fellow (Research Department, KNU)
• 2009 - 2013 Research Fellow (Research Department, KNU)
• 2013 - 2021 Senior Research Fellow (Research Department, KNU)
• 2011 - 2021 Associate Professor (Dept. of Plants Physiology, Biochemistry and Bioenergetics, NULES; part time
• 2021- till now Head of Department of Plants Physiology, Biochemistry and Bioenergetics, NULES

Specialization:

1. main fields: Biochemistry, Biotechnology 
2. other fields: Biomaterials, Biophysics
3. current research interest: Biochemical mechanisms of action and technology of applying nanomaterials

Courses taught:

• Biochemistry
• Ecotrophology
• Introduction to Вiotechnology
• Cell Bioenergetics

Honours, Awards, Fellowships, Membership of Professional Societies:

• 2002-2003 Leonhard-Euler DAAD Scholarship (Technical University of Ilmenau, Germany)
• 2002-2004 BMBF grant (Technical University of Ilmenau, Germany; N Ukr 02-007)
• 2003-2005 SSTP grant of Ministry of Education and Science of Ukraine (N DP/149-2003)
• 2004 The Kyiv City Administration Award for the scientific progresses
• 2005-2007 BMBF grant (Technical University of Ilmenau, Germany; N Ukr 05-008)
• 2006-2007 INTAS Young Scientist Fellowship (N 05-109-4328)
• 2007-2008 Bilaterial Ukrainian-Hungarian grant (Research Institute for Solid State Physics and Optics, Dept. of Neutron Spectroscopy, Budapest, Hungary)
• 2007-2008 BMBF grant (Technical University of Ilmenau, Germany; N Ukr 07-003)
• 2010 DFG grant (Technical University of Ilmenau, Ilmenau, Germany)
• 2010 DAAD Scholarship (Technical University of Ilmenau, Institute of Chemistry and Biotechnology, Ilmenau, Germany)
• 2010-2012 BMBF grant (Technical University of Ilmenau, Institute of Chemistry and  Biotechnology, Ilmenau, Germany; N Ukr 10-012)
• 2012 Grant of Ministry of Education and Science of Ukraine (Technical University of  Ilmenau, Institute of Chemistry and Biotechnology, Germany)
• 2014 DAAD Scholarship (Technical University of Ilmenau, Institute of Chemistry and Biotechnology, Ilmenau, Germany; Laboratory of Prof. U. Ritter)
• Winner of the All-Ukrainian Competition "Invention-2010" in the field of  "Medicine, Biotechnology, Agriculture" for package of inventions "Using nanotechnology for malignant neoplasms treatment"
• 2011 The Cabinet of Ministers of Ukraine Award for outstanding achievements of young scientists
• 2013 Winner of the All-Ukrainian Competition "Invention-2012" (1st place) for  invention "Using pristine C60 fullerenes as anticancer agents in the malignant neoplasms treatment"
• 2013 World Intellectual Property Organization (WIPO) Award for best inventor
• 2014 Taras Shevchenko Award of KNU for scientific achievements
• 2015 Kostyuk Foundation Award for outstanding achievements in the biomedical research field
• 2019 DAAD Scholarship (Technical University of Ilmenau, Institute of Chemistry and Biotechnology & Technical University of Applied Sciences Wildau, Germany)
• 2019 DFG grant (Project Coordinator: Prof. U. Ritter, Ilmenau Technical University,  Institute of Chemistry and Biotechnology, Ilmenau, Germany; N RI 966/19-1)
• 2020-2021 National Research Foundation of Ukraine grant (N 2020.01/0044)
• 2020-2021 National Research Foundation of Ukraine grant (N 2020.02/0060)
• 2002 - till now Membership of the Ukrainian Biochemical Society

Publications:

Number of monographs: 3;

Number of papers in refereed journals: 116;

Number of patents: 5

LIST OF SELECTED PUBLICATIONS:

Book Section

1. Matyshevska O.P., Palyvoda K.O., Prylutska S.V., Grynyuk I.I., Pasechnik A.V., Petuchov D.N., Drobot L.B. Induction of apoptotic death of leukemic cells using fullerene C60 (Editors: A.G. Naumovets et al); Nanoscale systems and nanomaterials: research in Ukraine. Kiev, Academperiodic, 2014. P. 524-529.

2. Matyshevska O.P., Drobot L.B., Prylutska S.V., Grynyuk I.I., Palyvoda K.O., Petuchov D.N. Fullerene C60 as modulator of apoptosis of T-lymphocytes precursors and leukemic cells (Editors: R.S. Stoika et al); Multifunctional Nanomaterials for Biology and Medicine: molecular design, synthesis and application. Кyiv, Naukova Dumka, 2017. P. 114-126.

Patents

1. Yu.P. Rud, S.V. Prylutska, L.P. Buchatskyy, Yu.I. Prylutskyy. (2012): Application of C60 fullerenes for photodynamic inactivation of mosquito iridovirus. UA Patent (Patent No 97316).  

2. S.V. Prylutska, A.P. Burlaka, Yu.I. Prylutskyy. (2012): Application of pristine C60 fullerenes as anticancer agents in the therapy of malignant tumors. UA Patent (Patent No 98076).  

3. S.V. Prylutska. (2013): Method of treating malignant tumors with combination of unmodified fullerenes C60 and doxorubicin. UA Patent (Patent No 102139).  

Original Papers

1. S. Prylutska, R. Bilyy, M. Overchuk, A. Bychko, K. Andreichenko, R. Stoika, V. Rybalchenko, Yu. Prylutskyy, N.G. Tsierkezos, U. Ritter. Water-soluble pristine fullerenes C60 increase the specific conductivity and capacity of lipid model membrane and form the channels in cellular plasma membrane. J. Biomed. Nanotechnol., 2012, V. 8, N 3, P. 522-527. DOI: 10.1166/jbn.2012.1404 (Q1 – Bioengineering)

2. G.B. Skamrova, I.V. Laponogov, A.S. Buchelnikov, Y.G. Shckorbatov, S.V. Prylutska, U. Ritter, Y.I. Prylutskyy, M.P. Evstigneev. Interceptor effect of C60 fullerene on the in vitro action of aromatic drug molecules. Eur. Biophys. J., 2014, V. 43, N 6-7, P. 265-276. DOI: 10.1007/s00249-014-0960-2 (Q1 - Medicine) 

3. S. Prylutska, I. Grynyuk, O. Matyshevska, Yu. Prylutskyy, M. Evstigneev, P. Scharff, U. Ritter. C60 fullerene as synergistic agent in tumor-inhibitory doxorubicin treatment. Drugs R D, 2014, V. 14, N 4, P. 333-340.

4. R.R. Panchuk, S.V. Prylutska, V.V. Chumak, N.R. Skorokhyd, L.V. Lehka, M.P. Evstigneev, Yu.I. Prylutskyy, W. Berger, P. Heffeter, P. Scharff, U. Ritter, R.S. Stoika. Application of С60 fullerene-doxorubicin complex for tumor cell treatment in vitro and in vivo. J. Biomed. Nanotechnol., 2015, V. 11, N 7, P. 1139-1152. DOI: 10.1166/jbn.2015.2058

(Q1 – Pharmaceut Sci)

5. S. Prylutska, L. Skivka, G. Didenko, Yu. Prylutskyy, M. Evstigneev, G. Potebnya, R. Panchuk, R. Stoika, U. Ritter, P. Scharff. Complex of C60 fullerene with doxorubicin as a promising agent in antitumor therapy. Nanoscale Res. Lett., 2015, V. 10: 499. DOI: 10.1186/s11671-015-1206-7 (Q2 – Nanosci Nanotechnol)

6. Yu. Prylutskyy, A. Bychko, V. Sokolova, S. Prylutska, M. Evstigneev, V. Rybalchenko, M. Epple, P. Scharff. Interaction of C60 fullerene complexed to doxorubicin with model bilipid membranes and its uptake by HeLa cells. Mater. Sci. Engineer. C., 2016, V. 59, P. 398-403. DOI: 10.1016/j.msec.2015.10.049 (Q1 – Mater Sci)

7. Franskevych D., Palyvoda K., Petukhov D., Prylutska S., Grynyuk I., Schuetze C., Drobot L., Matyshevska O., Ritter U. Fullerene C60 Penetration into Leukemic Cells and Its Photoinduced Cytotoxic Effects. Nanoscale Res. Lett., 2017, V. 12: 49. (Q2 – Nanosci Nanotechnol)

8. S. Prylutska, I. Grynyuk, A. Grebinyk, V. Hurmach, Iu. Shatrava, T. Sliva, V. Amirkhanov, Yu. Prylutskyy, O. Matyshevska, M. Slobodyanik, M. Frohme, U. Ritter. Cytotoxic effects of dimorfolido-N-trichloroacetylphosphorylamide and dimorfolido-N-benzoylphosphorylamide in combination with C60 fullerene on leukemic cells and docking study of their interaction with DNA. Nanoscale Res. Lett., 2017, V. 12: 124. DOI: 10.1186/s11671-017-1893-3 (Q2 – Nanosci Nanotechnol)

9. S.V. Prylutska, S.V. Politenkova, K.S. Afanasieva, V.F. Korolovych, K.I. Bogutska, A.V. Sivolob, L.M. Skivka, M.P. Evstigneev, V.V. Kostjukov, Yu.I. Prylutskyy, U. Ritter. A nanocomplex of С60 fullerene with cisplatin: design, characterization and toxicity. Beilstein J. Nanotechnol., 2017, V. 8, P. 1494-1501. DOI: 10.3762/bjnano.8.149 (Q1 - Mater Sci)

10. S. Prylutska, R. Panchuk, G. Gołuński, L. Skivka, Yu. Prylutskyy, V. Hurmach, N. Skorokhyd, A. Borowik, A. Woziwodzka, J. Piosik, O. Kyzyma, V. Haramus, L. Bulavin, M.  Evstigneev, A. Buchelnikov, R. Stoika, W. Berger, U. Ritter, P. Scharff. С60 fullerene enhances cisplatin anticancer activity and overcomes tumor cells drug resistance. Nano Res., 2017, V. 10, N 2, P. 652-671. DOI: 10.1007/s12274-016-1324-2 (Q1 – Nanosci Nanotechnol)

11. A. Grebinyk, S. Grebinyk, S. Prylutska, U. Ritter, O. Matyshevska, T. Dandekar, M. Frohme. C60 fullerene accumulation in human leukemic cells and perspectives of LED-mediated photodynamic therapy. Free Radic. Biol. Med., 2018, V. 124, P. 319–327. (Q1 – Biochemistry)

12. L.M. Skivka, S.V. Prylutska, M.P. Rudyk, N.M. Khranovska, I.V. Opeida, V.V. Hurmach, Yu.I. Prylutskyy, L.F. Sukhodub, U. Ritter. C60 fullerene and its nanocomplexes with anticancer drugs modulate circulating phagocyte functions and dramatically increase ROS generation in transformed monocytes. Cancer Nanotechnol., 2018, V. 9:8. DOI: 10.1186/s12645-017-0034-0 (Q1 – Biomed Engineer)

13. T. Matvienko, V. Sokolova, S. Prylutska, Yu. Harahuts, N. Kutsevol, V. Kostjukov, M. Evstigneev, Yu. Prylutskyy, M. Epple, U. Ritter. In vitro study of the anticancer activity of various doxorubicin-containing dispersions. BioImpacts, 2019, V. 9, N 1, P. 57-63. DOI: 10.15171/bi.2019.07 (Q1 – Pharmaceut Sci)

14. V. Bilobrov, V. Sokolova, S. Prylutska, R. Panchuk, O. Litsis, V. Osetskyi, M. Evstigneev, Yu. Prylutskyy, M. Epple, U. Ritter. A novel nanoconjugate of Landomycin A with C60 fullerene for cancer targeted therapy: in vitro studies. Cell. Mol. Bioengineer., 2019, V. 12, N 1, P. 41-51. doi: 10.1007/s12195-018-0548-5  (Q1 – Model Simulation)   

15. A. Grebinyk, S. Prylutska, S. Grebinyk, Yu. Prylutskyy, U. Ritter, O. Matyshevska, T. Dandekar, M. Frohme. Complexation with C60 fullerene increases doxorubicin efficiency against leukemic cells in vitro. Nanoscale Res. Lett., 2019, V. 14: 61. https://doi.org/10.1186/s11671-019-2894-1 (Q2 – Nanosci Nanotechnol)

16. S.V. Prylutska, I.I. Grynyuk, T.D. Skaterna, I.R. Horak, A.G. Grebinyk, L.B. Drobot, O.P. Matyshevska, A.I. Senenko, Yu.I. Prylutskyy, A.G. Naumovets, U. Ritter, M. Frohme. Toxicity of C60 fullerene-сisplatin nanocomplex against Lewis lung carcinoma cells. Arch. Toxicol., 2019, V. 93, N 5, P. 1213-1226. DOI: 10.1007/s00204-019-02441-6 (Q1 – Toxicology)

17. S.V. Prylutska, O.V. Lynchak, V.V. Kostjukov, M.P. Evstigneev, O.V. Remeniak, V.K. Rybalchenko, Yu.I. Prylutskyy, U. Ritter, P. Scharff. Antitumor effects and hematotoxicity of С60-Cis-Pt nanocomplex in mice with Lewis lung carcinoma. Exp. Oncol., 2019, V. 41, N 2, P. 106-111.

18. L.B. Sukhodub, L.F. Sukhodub, M.O. Kumeda, S.V. Prylutska, V. Deineka, Yu.I. Prylutskyy, U. Ritter. C60 fullerene loaded hydroxyapatite-chitosan beads as a promising system for prolonged drug release. Carbohydrate Polym., 2019, V. 223: 115067. https://doi.org/10.1016/j.carbpol.2019.115067 (Q1 – Mater Chem)

19. S.V. Prylutska, A.G. Grebinyk, O.V. Lynchak, I.V. Byelinska, V.V. Cherepanov, E. Tauscher, O.P. Matyshevska, Yu.I. Prylutskyy, V.K. Rybalchenko, U. Ritter, M. Frohme. In vitro and in vivo toxicity of pristine C60 fullerene aqueous colloid solution. Fullerenes, Nanotubes, Carbon Nanostruct., 2019, V. 27, N 9, P. 715-728. https://doi.org/10.1080/1536383X.2019.1634055 (Q2 – Mater Sci)

20. A. Grebinyk, S. Prylutska, O. Chepurna, S. Grebinyk, Yu. Prylutskyy, U. Ritter, T.Y. Ohulchanskyy, O. Matyshevska, T. Dandekar, M. Frohme. Synergy of chemo- and photodynamic therapies with C60 fullerene-doxorubicin nanocomplex. Nanomater., 2019, V. 9, N 11: 1540. doi: 10.3390/nano9111540 (Q1 – Mater Sci)

21. A. Grebinyk, S. Prylutska, A. Buchelnikov, N. Tverdokhleb, S. Grebinyk, M. Evstigneev, O. Matyshevska, V. Cherepanov, Yu. Prylutskyy, V. Yashchuk, A. Naumovets, U. Ritter, T. Dandekar, M. Frohme. C60 fullerene as effective nanoplatform of alkaloid berberine delivery into leukemic cells. Pharmaceutics, 2019, V. 11, N 11: 586. DOI: 10.3390/pharmaceutics11110586 (Q1 – Pharmaceut Sci)

22. D. Franskevych, S. Prylutska, I. Grynyuk, G. Pasichnyk, L. Drobot, O. Matyshevska, U. Ritter. Mode of photoexcited C60 fullerene involvement in potentiating of cisplatin toxicity against drug resistance L1210 cells. BioImpacts, 2019, V. 9, N 4: 217. (Q1 – Pharmaceut Sci)

23. N. Strutynska, O. Livitska, S. Prylutska, Yu. Yumyna, P. Zelena, L. Skivka, A. Malyshenko, L. Vovchenko, V. Strelchuk, Yu. Prylutskyy, N. Slobodyanik, U. Ritter. New nanostructured apatite-type (Na+, Zn2+, CO32−)-doped calcium phosphates: Preparation, mechanical properties and antibacterial activity. J. Mol. Struct., 2020, V. 1222: 128932. DOI: 10.1016/j.molstruc.2020.128932 (Q2 – Analyt Chem)

24. Ye. Hurmach, M. Rudyk, S. Prylutska, V. Hurmach, Yu. Prylutskyy, U. Ritter, P. Scharff, L. Skivka. C60 Fullerene Governs Doxorubicin Effect on Metabolic Profile of Rat Microglial Cells In Vitro. Mol. Pharmaceutics, 2020, V. 17, P. 3622−3632. https://doi.org/10.1021/acs.molpharmaceut.0c00691 (Q1 - Pharmaceut Sci)

25. I.I. Grynyuk, O.M. Vasyliuk, S.V. Prylutska, N.Yu. Strutynska, O.V. Livitska, M.S. Slobodyanik. Influence of nanoscale-modified apatite-type calcium phosphates on the biofilm formation by pathogenic microorganisms. Open Chemistry, 2021, V. 19, P. 39-48.

26. D. Nozdrenko, O. Abramchuk, S. Prylutska, O. Vygovska, V. Soroca, K. Bogutska, S. Khrapatyi, Yu. Prylutskyy, P. Scharff, U. Ritter. Analysis of Biomechanical Parameters of Muscle Soleus Contraction and Blood Biochemical Parameters in Rat with Chronic Glyphosate Intoxication and Therapeutic Use of C60 Fullerene. Int. J. Mol. Sci., 2021, V. 22, N 9: 4977. DOI: 10.3390/ijms22094977  (Q1 – Medicine)

27. M. Chernykh, D. Zavalny, V. Sokolova, S. Ponomarenko, S. Prylutska, Yu. Kuziv, V. Chumachenko, A. Marynin, N. Kutsevol, M. Epple, U. Ritter, J. Piosik, Yu. Prylutskyy. A New Water-Soluble Thermosensitive Star-Like Copolymer as a Promising Carrier of the Chemotherapeutic Drug Doxorubicin. Materials, 2021, V. 14, N 13: 3517. https://doi.org/10.3390/ma14133517 (Q2 – Mater Sci)

28. O. Lynchak, I. Byelinska, N. Dziubenko, H. Kuznietsova, O. Abramchuk, S. Prylutska. Acute toxicity of C60–Cis-Pt nanocomplex in vivo. Appl. Nanosci., 2021. DOI10.1007/s13204-021-01680-3 (Q2 - Biotechnol)

29. S.V. Prylutska, D.V. Franskevych, A.I. Yemets. Cellular biological and molecular genetic effects of carbon nanomaterials in plant. Cytology and Genetics, 2022, 56(4):48-59. (Scopus, Q3).

PARTICIPATION IN THE INTERNATIONAL CONFERENCES:

Oral presentation: 17; Poster presentation: 87